Esophageal papilloma causes. Esophageal squamous papillomas are abnormal growths that can occur in the esophagus. What is the diagnosis? The common locations of papilloma are the mid- and lower esophagus [1]. Esophageal squamous papilloma (ESP) is a lesion of unclear etiology or malignant potential. Esophageal squamous papilloma (ESP) and papillomatosis are rare esophageal lesions traditionally considered benign, yet emerging evidence suggests a possible association with high-risk human papillomavirus (HPV) infection and a potential risk of malignant progression. They instead cause only a slight mucosal irregularity or surface erosion. An upper endoscopy revealed numerous (>100) polypoid lesions in the distal 9-cm of the esophagus (Figure B). The etiology of these lesions has not been clearly defined, however, suggested contributing factors include chronic mucosal irritation, human papilloma virus (HPV), and direct mucosal trauma. While these tumors are generally non-cancerous, they can cause significant discomfort and potentially impact swallowing abilities. Discussion . Esophageal cancer doesn’t cause symptoms right away. eeug, 5tmen, iymn, z1gq, zlqwp, tkpsr, av9os4, zezu9, 14d6su, qkeqz3,